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Welcome to ICG
A knowledgebase of Internal Control Genes for RT-qPCR normalization

ICG is a wiki-based knowledgebase of internal control genes (or reference genes) for RT-qPCR normalization in a variety of species across three domains of life. Based on community curation, ICG harnesses collective intelligence to integrate a comprehensive collection of internal control genes curated from a large volume of literatures and provides appropriate internal control genes corresponding to specific experimental conditions for both model and non-model organisms.

Nothing great is ever accomplished in isolation. – Yo-Yo Ma
Newly Curated Species
Canis lupus familiaris.png Bactrocera dorsalis.png Equus caballus.jpg Stenella coeruleoalba.png Haliotis rufescens.png
Domestic dog
Canis lupus familiaris
Oriental fruit fly
Bactrocera dorsalis
Equus caballus
Striped dolphin
Stenella coeruleoalba
Red abalone
Haliotis rufescens
Neurospora crassa.png Panax ginseng.png Glycine max.png Sedum alfredii.png Arachis hypogaea.png
Neurospora crassa
Neurospora crassa
Korean ginseng
Panax ginseng
Glycine max
Sedum alfredii
Arachis hypogaea

  >> More...

Figure 1. Omics Knowledge Portal for Rice
  • ICG-version 1.0 is online (June 6, 2017)
    • A total of 185 species are integrated in ICG, including 67 Animals, 106 Plants, 8 Fungi and 4 Bacteria
    • More than 70 kinds of experimental conditions are included, such as Salinity, Heat and Insecticide Treatment
    • 796 internal control genes with experimental validation are curated, such as EF1α, UBI and ACT
  • More than 200 literatures on Selection of Internal Control Genes are curated (May 20, 2017)
  • 3 literatures with miRNA as internal control genes for RT-qPCR normalization are curated and added in ICG (Apr 15, 2017)
  • The second round of literature research on ICG project is completed (Nov 20, 2016)
  • The first round of literature research on ICG project is completed (Oct 20, 2016)
  • ICG project is launched (Jul 30, 2016)
To be curated
Species Literature Year
Prunus persica 2017
Burkholderia pyrrocinia 2017
Shiraia bambusicola 2017
Poa pratensis 2017
Joining ICG
  • ICG allows any user to view and search but only registered users can add and edit content.
  • To become a registered user, please email the ICG Team at to tell us your preferred login name, real name, research interests, etc., and we will set up an account for you.
  • Please also spread this news to any one who might be of interest.
About Us
  • Our group works in the field of Computational Biology and Bioinformatics (CBB), currently with a particular focus on building biological knowledge wikis in aid of community curation of massive biological knowledge.
  • NOTICE: Since Jan. 2016, our group has been merged as a founding group into BIG Data Center (