Gene:Ubiquitin

Synonymous Genes

• Ubiquitin <=> UBQ10, Ubiquitin, Ubiquitin C

Experimental Validated ICGs

Species	Gene Synonymous	Application scenarios	Publication	Year
Agrostis stolonifera	E3 ubiquitin-protein ligase	Abiotic Stresses	Selection of reference genes for quantitative real-time PCR normalization in creeping bentgrass involved in four abiotic stresses	2015
Ammopiptanthus mongolicus	Ubiquitin	Abiotic Stresses	Reference gene selection for qPCR in Ammopiptanthus mongolicus under abiotic stresses and expression analysis of seven ROS-scavenging enzyme genes	2012
Anthurium andraeanum	Ubiquitin-like protein 5	Spathe Tissue	Identification of reference genes for expression studies using quantitative RT-PCR in spathe tissue of Anthurium andraeanum (Hort.)	2013
Bos indicus	Ubiquitin	Milk Somatic Cells	Selection of suitable reference genes for quantitative gene expression studies in milk somatic cells of lactating cows (Bos indicus)	2012
Bos taurus	Ubiquitin carboxyl-terminal hydrolase L5	Viral Infection	Evaluation of reference genes for qRT-PCR gene expression studies in whole blood samples from healthy and leukemia-virus infected cattle	2013
Brachiaria brizantha	Ubiquitin-conjugating enzyme	Different Sex & Tissues	Validation of internal reference genes for real-time quantitative polymerase chain reaction studies in the tick, Ixodes scapularis (Acari: Ixodidae)	2013
Brachypodium distachyon	Ubiquitin-conjugating enzyme 18	Different Tissues & Growth Conditions	Exercise induced stress in horses: selection of the most stable reference genes for quantitative RT-PCR normalization	2008
Brassica napus	Ubiquitin-conjugating enzyme 21	Abiotic & Biotic Stress	Selection of reference genes for quantitative reverse-transcription polymerase chain reaction normalization in Brassica napus under various stress conditions	2014
Brassica oleracea	Ubiquitin	Abiotic Stresses	Identification of suitable qPCR reference genes in leaves of Brassica oleracea under abiotic stresses	2014
Brassica rapa subsp. pekinensis	Ubiquitin-conjugating enzyme 30	Different Developmental Stages & Biotic Stress	Validation of reference genes for real-time quantitative PCR normalisation in non-heading Chinese cabbage	2012
Camellia sinensis	Ubiquitin-conjugating enzyme	Various Experimental Treatments	Identification and evaluation of reliable reference genes for quantitative real-time PCR analysis in tea plant (Camellia sinensis (L.) O. Kuntze)	2014
Capsicum annuum	Ubiquitin-conjugating protein	Different Tissues & Abiotic Stress & Hormonal Treatment	Identification of reference genes for reverse transcription quantitative real-time PCR normalization in pepper (Capsicum annuum L.)	2011
Coffea arabica L.	Polyubiquitin 10	Abiotic Stress	Nitrogen starvation, salt and heat stress in coffee (Coffea arabica L.): identification and validation of new genes for qPCR normalization	2013
Coffea arabica L.	Ubiquitin	Different Genotypes & Abiotic Stress	Selection of Reference Genes for Normalizing Quantitative Real-Time PCR Gene Expression Data with Multiple Variables in Coffea spp	2012
Corchorus capsularis	Ubiquitin-conjugating enzyme like protein, Ubiquitin extension protein	Different Tissues & Abiotic Stress	Selection of reliable reference genes for quantitative real-time PCR gene expression analysis in Jute (Corchorus capsularis) under stress treatments	2015
Cucumis melo	Ubiquitin extension protein	Abiotic Stress Conditions	Screening suitable reference genes for normalization in reverse transcription quantitative real-time PCR analysis in melon	2014
Cucumis sativus	Ubiquitin extension protein	Different Tissues & Hormones Treatment & abiotic stresses	Selection of appropriate reference genes for gene expression studies by quantitative real-time polymerase chain reaction in cucumber	2010
Cynodon dactylon	E3 ubiquitin-protein ligase	Abiotic Stress	Selection and validation of reference genes for target gene analysis with quantitative RT-PCR in leaves and roots of bermudagrass under four different abiotic stresses	2014
Danio rerio	Danio rerio ubiquitin-conjugating enzyme E2A (ube2a)	Different Developmental Stages & Tissues & Abiotic Stress	Genome-wide identification of suitable zebrafish Danio rerio reference genes for normalization of gene expression data by RT-qPCR	2016
Dimocarpus longan	Ubiquitin	Somatic Embryogenesis	Reference gene selection for qPCR analysis during somatic embryogenesis in longan tree	2010
Eremosparton songoricum	Ubiquitin	Different Tissues & Abiotic Stress	Reference gene selection in the desert plant Eremosparton songoricum	2012
Eucalyptus globulus	Ubiquitin C	Cold Acclimation	Validation of reference genes for real-time qRT-PCR normalization during cold acclimation in Eucalyptus globulus	2010
Eucalyptus grandis	Polyubiquitin	In Vitro Adventitious Rooting	Reference gene selection for quantitative reverse transcription-polymerase chain reaction normalization during in vitro adventitious rooting in Eucalyptus globulus Labill	2010
Gadus morhua	Ubiquitin	Different Tissues	Selection of reference genes for qRT-PCR examination of wild populations of Atlantic cod Gadus morhua	2008
Gossypium hirsutum	Ubiquitin extension protein 7	Abiotic Stress	Evaluation and selection of reliable reference genes for gene expression under abiotic stress in cotton (Gossypium hirsutum L.)	2013
Gossypium hirsutum	Ubiquitin extension protein	Fiber Development & Somatic Embryogenesis	Suitable internal control genes for qRT-PCR normalization in cotton fiber development and somatic embryogenesis	2007
Gossypium hirsutum	Ubiquilin	Different Developmental Stages & Tissues	Identification and evaluation of new reference genes in Gossypium hirsutum for accurate normalization of real-time quantitative RT-PCR data	2010
Hevea brasiliensis	Ubiquitin-conjugating enzyme E2	Different Genotypes & Abiotic Stress	Screening of valid reference genes for real-time RT-PCR data normalization in Hevea brasiliensis and expression validation of a sucrose transporter gene HbSUT3	2011
Hippoglossus hippoglossus	Ubiquitin-conjugating enzyme E2L 3	Different Development & Tissues	Evaluation of potential reference genes for real time RT-PCR studies in Atlantic halibut (Hippoglossus Hippoglossus L.); during development, in tissues of healthy and NNV-injected fish, and in anterior kidney leucocytes	2010
Homo sapiens	Ubiquitin C	Hepatocellular Carcinoma	Validation of putative reference genes for gene expression studies in human hepatocellular carcinoma using real-time quantitative RT-PCR	2008
Hordeum vulgare	Ubiquitin	Different Developmental stages	Internal standards for quantitative RT-PCR studies of gene expression under drought treatment in barley (Hordeum vulgare L.): the effects of developmental stage and leaf age	2012
Hyriopsis cumingii	Ubiquitin	During Biomineralization	Identification of housekeeping genes suitable for gene expression analysis in the pearl mussel, Hyriopsis cumingii, during biomineralization	2014
Ipomoea batatas	Ubiquitin extension protein	Abiotic Stress	Stable internal reference genes for the normalization of real-time PCR in different sweetpotato cultivars subjected to abiotic stress conditions	2012
Lilium davidii	Ubiquitin	Different Experimental Conditions	Validation of Reference Genes for Accurate Normalization of Gene Expression in Lilium davidii var. unicolor for Real Time Quantitative PCR	2015
Litsea cubeba	Ubiquitin-conjugating enzyme	Different Developmental Stages & Tissues	Identification of appropriate reference genes for normalizing transcript expression by quantitative real-time PCR in Litsea cubeba	2013
Lolium spp	Ubiquitin	Resistant to Acetolactate-Synthase Inhibitors	Reference genes to study herbicide stress response in Lolium sp.: up-regulation of P450 genes in plants resistant to acetolactate-synthase inhibitors	2013
Medicago sativa	Ubiquitin protein ligase 2a	Different Environmental & Developmental Regulation	Reference Genes for RT-qPCR Analysis of Environmentally and Developmentally Regulated Gene Expression in Alfalfa	2015
Musa acuminata	Ubiquitin2	Different Experimental Conditions	Validation of reference genes for RT-qPCR studies of gene expression in banana fruit under different experimental conditions	2011
Nicotiana tabacum	Ubiquitin-conjugating enzyme E2	Different Developmental Stages & Abiotic stress	Stable internal reference genes for normalization of real-time RT-PCR in tobacco (Nicotiana tabacum) during development and abiotic stress	2010
Octopus vulgaris	Ubiquitin	Brain	Selection and validation of a set of reliable reference genes for quantitative RT-PCR studies in the brain of the Cephalopod Mollusc Octopus vulgaris	2009
Oreochromis niloticus	Ubiquitin-conjugating enzyme	Different Tissues & Bacterial Infection	Evaluation of reference genes for quantitative real-time RT-PCR analysis of gene expression in Nile tilapia (Oreochromis niloticus)	2013
Paeonia suffruticosa	Ubiquitin conjugating enzyme	Flower Development & Different Cultivars	Selection of Reference Genes for Quantitative Real-Time PCR during Flower Development in Tree Peony (Paeonia suffruticosa Andr.)	2016
Patinopecten yessoensis	ubiquitin	Different Tissues & Developmental Stages	Identification of reference genes for qRT-PCR analysis in Yesso scallop Patinopecten yessoensis	2013
Pennisetum glaucum	Ubiquitin-conjugating enzyme E2	Abiotic Stress	Selection of suitable reference genes for assessing gene expression in pearl millet under different abiotic stresses and their combinations	2016
Pennisetum glaucum	Ubiquitin-conjugating enzyme	Different Tissues & Genotypes	Cloning and validation of reference genes for normalization of gene expression studies in pearl millet Pennisetum glaucum (L.) R. Br. by quantitative real-time PCR	2015
Peucedanum praeruptorum	Ubiquitin-conjugating enzyme 9	Abiotic Stresses ＆ Hormone Treatment & Different Tissues	Selection of reference genes for gene expression normalization in Peucedanum praeruptorum dunn under abiotic stresses, hormone treatments and different tissues	2016
Phytophthora parasitica	Ubiquitin-conjugating enzyme	Different Developmental Stages	Selection of internal control genes for real-time quantitative RT-PCR assays in the oomycete plant pathogen Phytophthora parasitica	2006
Pinus massoniana	Polyubiquitin 11	Different Tissues & Floral Organ Development & Abiotic Stress	Selection of Reference Genes for Real-Time Quantitative PCR in Pinus massoniana Post Nematode Inoculation	2016
Platycladus orientalis	Ubiquitin 10	Different Tissues & Abiotic Stress	Selection of reference genes for quantitative gene expression studies in Platycladus orientalis (Cupressaceae) using real-time PCR	2012
Plukenetia volubilis	Ubiquitin-conjugating enzyme	Different Developmental Stages & Tissues	Selection of Reliable Reference Genes for Gene Expression Studies of a Promising Oilseed Crop, Plukenetia volubilis, by Real-Time Quantitative PCR	2015
Posidonia oceanica	Ubiquitin-conjugating enzyme, Ubiquitin	Abiotic Stress	Reference genes assessment for the seagrass Posidonia oceanica in different salinity, pH and light conditions	2012
Pyropia yezoensis	Ubiquitin	Different Developmental Stages & Abiotic Stress	Selection of reference genes for gene expression normalization in Pyropia yezoensis using quantitative real-time PCR	2014
Rosa hybrida	Ubiquitin conjugating protein	Different Genotypes & Tissues & Abiotic Stress	Identification of superior reference genes for data normalisation of expression studies via quantitative PCR in hybrid roses (Rosa hybrida)	2011
Saccharomyces cerevisiae	E2 ubiquitin-conjugating protein	Various Physiological States	Validation of reference genes for quantitative expression analysis by real-time RT-PCR in Saccharomyces cerevisiae	2009
Salicornia europaea	Polyubiquitin, Ubiquitin-conjugating enzyme	Abiotic Stress	Validation of suitable reference genes for gene expression analysis in the halophyte Salicornia europaea by real-time quantitative PCR	2014
Salvia miltiorrhiza	Ubiquitin protein	Different Tissues	Characterization of reference genes for quantitative real-time PCR analysis in various tissues of Salvia miltiorrhiza	2010
Sedum alfredii	Ubiquitin conjugating enzyme 9	Sedum alfredii	Selection and validation of reference genes for real-time quantitative PCR in hyperaccumulating ecotype of Sedum alfredii under different heavy metals stresses	2013
Sesamum indicum	Ubiquitin 6	Different Developmental Stages & Abiotic Stress	Identification and testing of reference genes for Sesame gene expression analysis by quantitative real-time PCR	2013
Solanum lycopersicum	Ubiquitin	Viral Infection	Evaluation of reference genes for quantitative reverse�\transcription polymerase chain reaction normalization in infected tomato plants	2010
Solanum tuberosum	ubiquitin-specific protease 22	Parasitic Infection	Identification of Reference Genes for Normalizing RNA Expression in Potato Roots Infected with Cyst Nematodes	2013
Spodoptera litura	Ubiquinol-cytochrome c reductase	Abiotic & Biotic treatments	Identification and validation of reference genes for gene expression analysis using quantitative PCR in Spodoptera litura (Lepidoptera: Noctuidae)	2013
Stipa grandis	Ubiquitin-conjugating enzyme 15, Ubiquitin-conjugating enzyme E2-17, Ubiquitin-conjugating enzyme E2 2	Abiotic Stress	Selection of Reference Genes for qRT-PCR Analysis of Gene Expression in Stipa grandis during Environmental Stresses	2017
Sus scrofa	Poly-ubiquitin	Oocytes & Preimplantation Embryos	Validation of reference genes for quantitative RT-PCR studies in porcine oocytes and preimplantation embryos	2007
Trifolium pratense	Ubiquitin-conjugating enzyme E2	Different Tissues	A critique of widely used normalization software tools and an alternative method to identify reliable reference genes in red clover (Trifolium pratense L.)	2012
Vernicia fordii	Ubiquitin	Seed Development	Selection of reliable reference genes for gene expression studies using real-time PCR in tung tree during seed development	2012
Vitis vinifera	Ubiquitin-conjugating enzyme	Mycotic Infection	Reference gene selection and validation for the early responses to downy mildew infection in susceptible and resistant Vitis vinifera cultivars	2013

Featured Sequence

The Sequence of Homo sapiens Ubiquitin is displayed as example. 000001 CCCGCTGCTC ATAAGACTCG GCCTTAGAAC CCCAGTATCA GCAGAAGGAC ATTTTAGGAC GGGACTTGGG 000070 000071 TGACTCTAGG GCACTGGTTT TCTTTCCAGA GAGCGGAACA GGCGAGGAAA AGTAGTCCCT TCTCGGCGAT 000140 000141 TCTGCGGAGG GATCTCCGTG GGGCGGTGAA CGCCGATGAT TATATAAGGA CGCGCCGGGT GTGGCACAGC 000210 000211 TAGTTCCGTC GCAGCCGGGA TTTGGGTCGC AGTTCTTGTT TGTGGATCGC TGTGATCGTC ACTTGACAAT 000280 000281 GCAGATCTTC GTGAAGACTC TGACTGGTAA GACCATCACC CTCGAGGTTG AGCCCAGTGA CACCATCGAG 000350 000351 AATGTCAAGG CAAAGATCCA AGATAAGGAA GGCATCCCTC CTGACCAGCA GAGGCTGATC TTTGCTGGAA 000420 000421 AACAGCTGGA AGATGGGCGC ACCCTGTCTG ACTACAACAT CCAGAAAGAG TCCACCCTGC ACCTGGTGCT 000490 000491 CCGTCTCAGA GGTGGGATGC AAATCTTCGT GAAGACACTC ACTGGCAAGA CCATCACCCT TGAGGTCGAG 000560 000561 CCCAGTGACA CCATCGAGAA CGTCAAAGCA AAGATCCAGG ACAAGGAAGG CATTCCTCCT GACCAGCAGA 000630 000631 GGTTGATCTT TGCCGGAAAG CAGCTGGAAG ATGGGCGCAC CCTGTCTGAC TACAACATCC AGAAAGAGTC 000700 000701 TACCCTGCAC CTGGTGCTCC GTCTCAGAGG TGGGATGCAG ATCTTCGTGA AGACCCTGAC TGGTAAGACC 000770 000771 ATCACCCTCG AGGTGGAGCC CAGTGACACC ATCGAGAATG TCAAGGCAAA GATCCAAGAT AAGGAAGGCA 000840 000841 TTCCTTCTGA TCAGCAGAGG TTGATCTTTG CCGGAAAACA GCTGGAAGAT GGTCGTACCC TGTCTGACTA 000910 000911 CAACATCCAG AAAGAGTCCA CCTTGCACCT GGTACTCCGT CTCAGAGGTG GGATGCAAAT CTTCGTGAAG 000980 000981 ACACTCACTG GCAAGACCAT CACCCTTGAG GTCGAGCCCA GTGACACTAT CGAGAACGTC AAAGCAAAGA 001050 001051 TCCAAGACAA GGAAGGCATT CCTCCTGACC AGCAGAGGTT GATCTTTGCC GGAAAGCAGC TGGAAGATGG 001120 001121 GCGCACCCTG TCTGACTACA ACATCCAGAA AGAGTCTACC CTGCACCTGG TGCTCCGTCT CAGAGGTGGG 001190 001191 ATGCAGATCT TCGTGAAGAC CCTGACTGGT AAGACCATCA CTCTCGAAGT GGAGCCGAGT GACACCATTG 001260 001261 AGAATGTCAA GGCAAAGATC CAAGACAAGG AAGGCATCCC TCCTGACCAG CAGAGGTTGA TCTTTGCCGG 001330 001331 AAAACAGCTG GAAGATGGTC GTACCCTGTC TGACTACAAC ATCCAGAAAG AGTCCACCTT GCACCTGGTG 001400 001401 CTCCGTCTCA GAGGTGGGAT GCAGATCTTC GTGAAGACCC TGACTGGTAA GACCATCACT CTCGAGGTGG 001470 001471 AGCCGAGTGA CACCATTGAG AATGTCAAGG CAAAGATCCA AGACAAGGAA GGCATCCCTC CTGACCAGCA 001540 001541 GAGGTTGATC TTTGCTGGGA AACAGCTGGA AGATGGACGC ACCCTGTCTG ACTACAACAT CCAGAAAGAG 001610 001611 TCCACCCTGC ACCTGGTGCT CCGTCTTAGA GGTGGGATGC AGATCTTCGT GAAGACCCTG ACTGGTAAGA 001680 001681 CCATCACTCT CGAAGTGGAG CCGAGTGACA CCATTGAGAA TGTCAAGGCA AAGATCCAAG ACAAGGAAGG 001750 001751 CATCCCTCCT GACCAGCAGA GGTTGATCTT TGCTGGGAAA CAGCTGGAAG ATGGACGCAC CCTGTCTGAC 001820 001821 TACAACATCC AGAAAGAGTC CACCCTGCAC CTGGTGCTCC GTCTTAGAGG TGGGATGCAG ATCTTCGTGA 001890 001891 AGACCCTGAC TGGTAAGACC ATCACTCTCG AAGTGGAGCC GAGTGACACC ATTGAGAATG TCAAGGCAAA 001960 001961 GATCCAAGAC AAGGAAGGCA TCCCTCCTGA CCAGCAGAGG TTGATCTTTG CTGGGAAACA GCTGGAAGAT 002030 002031 GGACGCACCC TGTCTGACTA CAACATCCAG AAAGAGTCCA CCCTGCACCT GGTGCTCCGT CTCAGAGGTG 002100 002101 GGATGCAAAT CTTCGTGAAG ACCCTGACTG GTAAGACCAT CACCCTCGAG GTGGAGCCCA GTGACACCAT 002170 002171 CGAGAATGTC AAGGCAAAGA TCCAAGATAA GGAAGGCATC CCTCCTGATC AGCAGAGGTT GATCTTTGCT 002240 002241 GGGAAACAGC TGGAAGATGG ACGCACCCTG TCTGACTACA ACATCCAGAA AGAGTCCACT CTGCACTTGG 002310 002311 TCCTGCGCTT GAGGGGGGGT GTCTAAGTTT CCCCTTTTAA GGTTTCAACA AATTTCATTG CACTTTCCTT 002380 002381 TCAATAAAGT TGTTGCATTC CCAAAAAAAA AAAAAAAA

Conserved Domains

The Conserved domains of Homo sapiens Ubiquitin is displayed as example.

External Links

• NCBI Conserved Protein Domain Family
• WikiPedia
• Pfam