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ICG is a wiki-based knowledgebase of internal control genes (or reference genes) for RT-qPCR normalization in a variety of species across three domains of life. Based on community curation, ICG harnesses collective intelligence to integrate a comprehensive collection of internal control genes curated from a large volume of literatures and provides appropriate internal control genes corresponding to specific experimental conditions for both model and non-model organisms.


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Purpose & Aims

The purpose of ICG is as follows.

  • Establish a community-based system to curate RT-qPCR internal control genes across different tissues and different experimental conditions for both model and non-model organisms.
  • Provide up-to-date, comprehensive, and professional informations about internal control genes for molecular biologists to carry out their RT-qPCR experiments.
  • Build related wiki extensions to ease content accessibility, adding and editing.



We thank a number of users for sharing their valuable knowledge, making edits, sending suggestions and reporting bugs.


ICG is supported by grants from:

  • Strategic Priority Research Program of the Chinese Academy of Sciences [XDB13040500 and XDA08020102 to Z.Z.; XDA08020102 to S.H.];
  • National Programs for High Technology Research and Development [2015AA020108 and 2012AA020409 to Z.Z.];
  • International Partnership Program of the Chinese Academy of Sciences [153F11KYSB20160008];
  • The 100-Talent Program of Chinese Academy of Sciences [to Y.B and Z.Z.];
  • National Natural Science Foundation of China [31100915 to L.H.].