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- Ticks are highly efficient arthropod vectors of infectious diseases, being able to transmit viruses, bacteria, protozoa, and helminth parasites. The tick Ixodes scapularis (= Ixodes dammini) is a vector for such human diseases as Lyme borreliosis, human granulocytic anaplasmosis (= ehrlichiosis), and babesiosis in the Central and Eastern United States. I. scapularis belongs to the subarctic Ixodes persulcatus complex of species that include Ixodes ricinus and Ixodes pacificus, vectors of Lyme disease in Asia, Europe and the western US, respectively.
- I. scapularis has three life stages after hatching from the egg: larvae and nymphs feed normally on small rodents, while adults feed on medium to large mammals. After finding a suitable site to feed, hard ticks penetrate the host skin with their mandibles and secrete a glue-like substance that helps to anchor and prevent detachment of the arthropod from the feeding site. Feeding may be accomplished in days or weeks, by the end of which the tick usually has increased in weight by up to 1000 fold its initial size. Feeding is accomplished by sucking blood from a hematoma, or pool of blood, formed in the host skin by mouthpart laceration of the host tissues.
- Maintenance of the liquid state of this pool is accomplished by a complex mixture of antihemostatic compounds present in tick saliva. Indeed, ticks alternately feed and salivate in the host skin. Tick saliva also contains antiinflammatory and immunomodulatory compounds that prevent immune reactions from disrupting the feeding process. Probably due to these pharmacologic activities, saliva enhances pathogen transmission, and antisaliva immunity affects pathogen transmission. Accordingly, knowledge of salivary components in vector ticks can lead to the discovery of novel pharmacologic molecules and to the development of novel transmission-blocking vaccine targets against the diseases that ticks transmit .
Different Feeding Phases
|Gene Symbol||Gene Name||Application Scope||Accession Number||Primers (5'-3')
|Size [bp]||Tm [℃]||Detection|
|rps4||ribosomal protein S4||
|l13a||Ribosomal protein L13A||
- Name: YOONSEONG PARK
- Email: firstname.lastname@example.org
- Institution: Department of Entomology, Kansas State University, 123 Waters Hall, Manhattan, KS 66506
Cited by 17 (Based on Google Scholar [2017-06-16])
- Koči J, Šimo L, Park Y. Validation of internal reference genes for real-time quantitative polymerase chain reaction studies in the tick, Ixodes scapularis (Acari: Ixodidae)[J]. Journal of medical entomology, 2013, 50(1): 79-84.
- Kaufman W R. Tick-host interaction: a synthesis of current concepts[J]. Parasitology today, 1989, 5(2): 47-56.