Difference between revisions of "Leptospira interrogans"
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* Leptospires are spirochete bacteria classified into nonpathogenic, intermediate, or pathogenic species and inhabit soil and freshwater reservoirs, predominately in tropical regions (1). Infection with pathogenic Leptospira spp. can result in a large range of clinical manifestations, including fever, renal failure, jaundice, hemorrhage, meningitis, and death. Leptospirosis, the severe manifestation of disease, has an annual global incidence of over 1 million human cases and a case fatality rate of from 5% to 20%.<ref name="ref1"/> <ref name="ref2"/>. | * Leptospires are spirochete bacteria classified into nonpathogenic, intermediate, or pathogenic species and inhabit soil and freshwater reservoirs, predominately in tropical regions (1). Infection with pathogenic Leptospira spp. can result in a large range of clinical manifestations, including fever, renal failure, jaundice, hemorrhage, meningitis, and death. Leptospirosis, the severe manifestation of disease, has an annual global incidence of over 1 million human cases and a case fatality rate of from 5% to 20%.<ref name="ref1"/> <ref name="ref2"/>. | ||
Revision as of 04:55, 26 June 2017
Contents
Description
- Leptospires are spirochete bacteria classified into nonpathogenic, intermediate, or pathogenic species and inhabit soil and freshwater reservoirs, predominately in tropical regions (1). Infection with pathogenic Leptospira spp. can result in a large range of clinical manifestations, including fever, renal failure, jaundice, hemorrhage, meningitis, and death. Leptospirosis, the severe manifestation of disease, has an annual global incidence of over 1 million human cases and a case fatality rate of from 5% to 20%.[1] [2].
- NCBI Taxonomy
Different Tissues & Abiotic Stress
Reference Genes
| Gene Symbol | Gene Name | Application Scope | Accession Number | Primers (5'-3') [Forward/Reverse] |
Size [bp] | Tm [℃] | Detection |
|---|---|---|---|---|---|---|---|
| EF1A2[1] | Eukaryotic translation elongation factor 1 alpha 2 |
|
BC108110.1 |
|
196 | 60 | SYBR |
| HMBS[1] | Hydroxymethylbilane synthase |
|
BC112573.1 |
|
81 | 60 | SYBR |
| SF3A1[1] | Splicing factor 3 subunit 1 |
|
NM_001081510.1 |
|
106 | 60 | SYBR |
Molecular Types
- mRNA
Evaluation Methods
- geNorm method && Related Reference
- NormFinder method && Related Reference
- BestKeeper method && Related Reference
- Ref-Finder method && Related Reference
- ΔCt approach method && Related Reference
Contact
- Name: A. de la Peña-Moctezuma
- Email: delapema@servidor.unam.mx
- Institution: Departamento de Microbiologı́a e Inmunologı́a, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Coyoacán 04510, México.
Citation Statistics
Cited by 33 (Based on Google Scholar [2017-06-23])
References
- ↑ 1.0 1.1 1.2 1.3 Carrillo-Casas EM, Hernández-Castro R, Suárez-Güemes F, de la Peña-Moctezuma A. Selection of the internal control gene for real-time quantitative rt-PCR assays in temperature treated Leptospira. Curr Microbiol. 2008 Jun;56(6):539-46. doi: 10.1007/s00284-008-9096-x. Epub 2008 Mar 18. PubMed PMID: 18347854.
- ↑ Eshghi A, Pappalardo E, Hester S, Thomas B, Pretre G, Picardeau M. Pathogenic Leptospira interrogans exoproteins are primarily involved in heterotrophic processes. Infect Immun. 2015 Aug;83(8):3061-73. doi: 10.1128/IAI.00427-15. Epub 2015 May 18. PubMed PMID: 25987703; PubMed Central PMCID: PMC4496612.
