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- The cynomolgus monkey (Macaca fascicularis) is one of the most commonly used nonhuman primate animal models for studying various diseases, such as inflammation, atherogenesis, chronic wasting disease (CWD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease, Alzheimer’s disease, and chikungunya disease because of its biological and behavioral similarities to, and close genetic relationship with, humans. Among the genus Macaca, the rhesus monkey (Macaca mulatta) is more widely used than the cynomolgus monkey for biomedical research.
- However, studies using rhesus monkeys were restricted due to an export ban of the rhesus monkey from India in 1977. This restriction led to the increased use of the cynomolgus monkey in various studies. Moreover, the cynomolgus monkey has several advantages over the rhesus monkey, including easy handling due to its smaller body size and weight, low cost and ease of availability, and lack of seasonal fertility.
- Moreover, researchers have access to more abundant gene information via numerous full-length mRNA sequences than in the case of rhesus macaques. Therefore, the cynomolgus monkey could be a valuable experimental nonhuman primate animal model for various studies .
Different Whole-body Tissues
|Gene Symbol||Gene Name||Application Scope||Accession Number||Primer||Size [bp]||Tm [℃]||Detection|
|ARFGAP2||ADP-ribosylation factor GTPase activating protein 2||
|MRFAP1||Morf4 family associated protein 1||
|ARL1||ADP-ribosylation factor-like 1||
- geNorm method && Related Reference
- NormFinder method && Related Reference
- BestKeeper method && Related Reference
- Name: Heui-Soo Kim
- Email: email@example.com
- Institution: National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea
Cited by 15 (Based on Google Scholar [2017-06-16])
- Park S J, Kim Y H, Huh J W, et al. Selection of new appropriate reference genes for RT-qPCR analysis via transcriptome sequencing of cynomolgus monkeys (Macaca fascicularis)[J]. PLoS One, 2013, 8(4): e60758.
- De Pablos V, Barcia C, Martinez S, Gomez A, Ros-Bernal F, et al. (2009) MPTP administration increases plasma levels of acute phase proteins in non-human primates (Macaca fascicularis). Neurosci Lett 463: 37–39.