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- Neurospora crassa has served as a model organism for studying circadian pathways and more recently has gained attention in the biofuel industry due to its enhanced capacity for cellulase production. However, in order to optimize N. crassa for biotechnological applications, metabolic pathways during growth under different environmental conditions must be addressed.
- Neurospora crassa is a filamentous fungus that has served for nearly 50 years as the model organism for studying circadian pathways and the molecular clock in eukaryotes.
- It is classified under the phylum Ascomycota and is widely distributed in nature, typically found growing on vegetation killed by fire. As such, it is able to synthesize and secrete high levels of all main enzyme types involved in lignocellulosic biomass degradation and is also able to convert pentose sugars, cellulose polymers, and agro-industrial residues to ethanol .  .
Different Environmental Conditions
|Gene Symbol||Gene Name||Application Scope||Accession Number||Primers (5'-3')
|Size [bp]||Tm [℃]||Detection|
|asl||ATP synthase lyase gamma subunit||
|vma1||vacuolar ATPase subunit 1||
|tbp||TATA binding box protein||
|vma2||vacuolar ATPase subunit 2||
- Name: Kathleen D. Cusick
- Email: Kathleen_cusick.firstname.lastname@example.org
- Institution: National Research Council Associateship, U.S. Naval Research Laboratory, Washington, District of Columbia, United States of America
Cited by 4 (Based on Google Scholar [2017-06-01])
- Cusick KD, Fitzgerald LA, Pirlo RK, et al. (2014) Selection and evaluation of reference genes for expression studies with quantitative PCR in the model fungus Neurospora crassa under different environmental conditions in continuous culture. PLoS One 9, e112706
- Baker CL, Loros JJ, Dunlap JC (2012) The circadian clock of Neurospora crassa. Fems Microbiology Reviews 36, 95-110.